PUBLICATIONS

*° Denotes equal contributions

2024

Ozonoff A*, Jayavelu ND*, Liu S, Melamed E*, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, MD8, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB , Steen H, Syphurs C, Dandekar R, Shannon CP1, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Metcalf JP, Hough CL, Messer WB,  Pulendran B, , Nadeau, KC, Davis MM, Fernandez Sesma A, Simon V, Bakel Hv, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS Erle DJ, Langelier CR, Eckalbar W, Bosinger S, IMPACC Network, Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC °, Montgomery RR°, Becker PM°, Rouphael N°. (2024) Features of acute COVID-19 associated with Post-Acute Sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nature Communications.;15(1):2161.

2023

Lyu A*, Humphrey RS*, Nam SH, Durham TA, Hu Z, Arasappan D, Horton TM, and Ehrlich LIR. (2023). Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia. Nat. Commun.14(1):6270. PMCID PMC10560206.

Li Y*, Tipan PG*, Selden HJ, Srinivasan J, Hale LP, Ehrlich LIR. (2023). CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance. eLife 12. doi:10.7554/elife.80443

Diray-Arce J, Fourati S, Jayavelu ND, Patel R, Maguire C, Chang AC, Dandekar R, Qi J, Lee BH, Zalm P van, Schroeder A, Chen E, Konstorum A, Brito A, Gygi JP, Kho A, Chen J, Pawar S, Gonzalez-Reiche AS, Hoch A, Milliren CE, Overton JA, Westendorf K, Network I, Abraham J, Adkisson M, Albert M, Torres LA, Alvarenga B, Anderson ML, Anderson EJ, Arnett A, Asashima H, Atkinson MA, Baden LR, Barton B, Beach K, Beagle E, Becker PM, Bell MR, Bernui M, Bime C, Kumar AB, Booth LJ, Borresen B, Brakenridge SC, Bristow L, Bryant R, Calfee CS, Manuel JC, Carrillo S, Chak S, Chang I, Connors J, Conway M, Corry DB, Cowan D, Croen B, Cruz CSD, Cusimano G, Eaker L, Edwards C, Ehrlich LIR, Elashoff D, Erickson H, Erle DJ, Farhadian S, Farrugia K, Fatou B, Fernandes A, Fernandez-Sesma A, Fragiadakis GK, Furukawa S, Geltman JN, Ghale R, Bermúdez MGC, Goonewardene MI, Sanchez EG, Guirgis FW, Hafler DA, Hamilton S, Harris P, Nemati AH, Hendrickson CM, Agudelo NIH, Hodder T, Holland SM, Hough CL, Huerta C, Hurley KC, Hutton SR, Iwasaki A, Jauregui A, Jha M, Johnson B, Joyner D, Kangelaris KN, Kelly G, Khalil Z, Khan Z, Kheradmand F, Kim JN, Kimura H, Ko AI, Kohr B, Kraft M, Krummel M, Kutzler MF, Lasky-Su J, Lee S, Lee D, Leipold M, Lentucci C, Leroux C, Lin E, Liu S, Love C, Lu Z, Maliskova L, Roth BM, Manohar M, Martens M, McComsey GA, McEnaney K, McLin R, Melamed E, Melnyk N, Mendez K, Messer WB, Metcalf JP, Michelotti G, Mick E, Mohanty S, Mosier J, Mulder LCF, Murphy M, Nadeau KRC, Nelson E, Nelson A, Nguyen V, Oberhaus J, Panganiban B, Pellegrini KL, Pickering HC, Powell DL, Presnell S, Pulendran B, Rahman AH, Sadeed AR, Raskin A, Reed EF, Pereira SR, Rivera AM, Rogers JE, Rogers A, Rogowski B, Rooks R, Rosenberg-Hasson Y, Rothman J, Rousseau JF, Salehi-Rad R, Saluvan M, Samaha H, Schaenman J, Schunk R, Semenza NC, Sen S, Sevransky J, Seyfert-Margolis V, Shaheen T, Shaw AC, Sieg S, Siegel SAR, Sigal N, Siles N, Simmons B, Simon V, Singh G, Sinko L, Smith CM, Smolen KK, Song L-Z, Srivastava K, Sullivan P, Syphurs C, Tcheou J, Tegos GP, Tharp GK, Ally AT, Tsitsiklis A, Ungaro RF, Vaysman T, Viode A, Vita R, Wang X, Ward A, Ward DC, Willmore A, Woloszczuk K, Wong K, Woodruff PG, Xu L, Haren S van, Guchte A van de, Zhao Y, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen L, Grubaugh ND, Bakel H van, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier CR, Levy O, Altman MC, Maecker H, Montgomery RR, Haddad EK, Sekaly RP, Esserman D, Ozonoff A, Becker PM, Augustine AD, Guan L, Peters B, Kleinstein SH. (2023) Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients. Cell Rep Med 4:101079. doi:10.1016/j.xcrm.2023.101079

Srinivasan J, Vasudev A, Selden HJ, Perez E, LaFleur B, Sinari SA, Krueger A, Richie ER, and Ehrlich LIR. (2023). An early decline in ETPs reflects reduced pre-thymic progenitors and altered signals from the thymus microenvironment. Aging Cell. doi:10.1111/acel.13870.

2022

Bazzi SA*, Maguire C *, Holay N, Geltman J, Hurley K, DiPasquale C, Abigania M, Olson E, Ehrlich LIR°, Triplett TA°, Melamed E°. Longitudinal COVID-19 immune trajectories in autoimmune patients on anti-CD20 therapy. Mult Scler Relat Dis. 2022;104195. PMCID: PMC9511881

Al Ozonoff*, Joanna Schaenman*, Naresh Doni Jayavelu*, Carly E. Milliren*, Carolyn S. Calfee, Charles B. Cairns, Monica Kraft, Lindsey R. Baden, Albert C. Shaw, Florian Krammer, Harm van Bakel, Denise A. Esserman, Ana Fernandez Sesma, Viviana Simon, David A. Hafler, Ruth R. Montgomery, Steven H. Kleinstein, Ofer Levy, , Chris Bime, Elias K. Haddad, David J. Erle, Bali Pulendran, R. Kari C. Nadeau, Mark M Davis, Catherine L. Hough, William B. Messer, Nelson I Agudelo Higuita, Jordan P. Metcalf, Mark A. Atkinson, Scott C. Brakenridge, David Corry, Farrah Kheradmand, Lauren I. R. Ehrlich, Esther Melamed, Grace A. McComsey, Rafick Sekaly, Joann Diray-Arce, Bjoern Peters , Alison D. Augustine, Elaine F. Reed, Matthew C. Altman**, Patrice M. Becker**, and Nadine Rouphael**, and the IMPACC study group members. (2022) Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study. eBioMedicine. 83:104208. PMCID: PMC9359694

Lancaster JN, Keatinge-Clay DL, Srinivasan J, Li Y, Selden HJ, Nam S, Richie ER, and Ehrlich LIR. (2022). Central tolerance is impaired in the middle-aged thymic environment. Biorxiv 2022.01.17.476690. In Press at Aging Cell (04/20/2022).

2021

IMPACC Manuscript Writing Team; IMPACC Network Steering Committee. Nadine Rouphael, Holden Maecker, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Matthew C Altman, Steven E Bosinger, Walter Eckalbar, Leying Guan, Catherine L Hough, Florian Krammer, Charles Langelier, Ofer Levy, Kerry McEnaney, Bjoern Peters, Adeeb Rahman, Jayant V Rajan, Steven Sigelman, Hanno Steen, Harm van Bakel, Alyssa Ward, Michael R Wilson, Prescott Woodruff, Colin R Zamecnik, Alison D Augustine, Al Ozonoff, Elaine F Reed, Patrice M Becker, Nelson Agudelo Higuita, Matthew C Altman, Mark A Atkinson, Lindsey R Baden, Patrice M Becker, Christian Bime, Scott C Brakenridge, Carolyn S Calfee, Charles B Cairns, David Corry, Mark M Davis, Alison D Augustine, Lauren I R Ehrlich, Elias K Haddad, David J Erle, Ana Fernandez-Sesma, David A Hafler, Catherine L Hough, Farrah Kheradmand, Steven H Kleinstein, Monica Kraft, Ofer Levy, Grace A McComsey, Esther Melamed, William Messer, Jordan Metcalf, Ruth R Montgomery, Kari C Nadeau, Al Ozonoff, Bjoern Peters, Bali Pulendran, Elaine F Reed, Nadine Rouphael, Minnie Sarwal, Joanna Schaenman, Rafick Sekaly, Albert C Shaw, Viviana Simon. (2021). Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study. Sci Immunol. 6(62). doi: 10.1126/sciimmunol.abf3733. PubMed PMID: 34376480

Srinivasan J*, Lancaster JN*, Singarapu N, Hale LP, Ehrlich LIR°, Richie ER°. Age-Related Changes in Thymic Central Tolerance. Front Immunol. 2021 Apr 22; 12:676236. doi:10.3389/fimmu.2021.676236

Wei SC, Meijers WC, Axelrod ML, Anang N-AAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand P-Y,  Mancuso JJ, Himmel LE, Lebrun0Vignes B, Wleklinski MJ, Knollmann BC, Srinivasan J, Li Y, Atolagbe OT, Rao X, Zhao Y, Wang J, Ehrlich LIR, Sharma P, Salem J-E, Balko JM, Moslehi JJ, Allison, JP. A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention. (2021). Cancer Discov. 11(3):614–25. PMCID: PMC8041233

Article Commentary: Young A and Bluestone JA. At the heart of immune checkpoint inhibitor-induced immune toxicity. (2021) Cancer Discov. 11(3):537-9.

2020

Lyu A*, Triplett TA*°, Nam SH, Hu Z, Arasappan D, Godfrey WH, Ames RY, Sarang A, Selden HJ, Lee C-H, Georgiou G, Horton TM, Ehrlich LIR°. (2020) Tumor-associated myeloid cells provide critical support for T-ALL. Blood. 136(16):1837-50.

Article Commentary: Diana Passaro. (2020) Myeloid cells hold the master key for T-ALL spread. Blood. 136 (16): 1799–1800

Warden AS, Triplett TA, Lyu A, Grantham EK, Azzam MM, DaCosta A, Mason S, Blednov YA, Ehrlich LIR, Mayfield DR, and Harris RA. (2020) Microglia depletion and alcohol: Transcriptome and behavioral profiles. Addiction Biology. 29(4):e12889

2019

Lancaster JN, Thyagarajan HM, Srinivasan J, Li Y, Hu Z, Ehrlich LIR. (2019) Live-cell imaging reveals the relative contributions of antigen presenting cell subsets to thymic central tolerance. Nature Communications.10(1):2220. link: https://rdcu.be/bCTkA

see: https://cns.utexas.edu/news/scientists-capture-first-ever-video-of-body-s-safety-test-for-t-cells

Jarrett AM, Bloom M, Godfrey W, Syed A, Ekrut DA, EhrlichLIR, Yankeelov TE, Sorace AG (2019) Mathematical modeling of trastuzumab-induced immune response in an in vivo murine model of HER2+ breast cancer.  Mathematical Medicine and Biology. 15: 730. PMID 30239754

2018

Singarapu N, Ma K, Reeh KAG, Shen J, Lancaster JN, Xie H, Orkin S, Manley NR, Ehrlich LIR, Jiang N, Richie ER.(2018) Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment. Scientific Reports. 8(1):14335. PMCID: PMC6156232

Triplett TA, Garrison KC, Marshall N, Donkor M, Blazeck J, Lamb C, Qerqez A, Dekker JD, Tanno Y, Lu WC, Karamitros CS, Ford K, Tan B, Zhang M, McGovern K, Coma S, Kumada Y, Yamany MS, Sentandreu E, Fromm G, Tiziani S, Schreiber TH, Manfredi M, Ehrlich LIR, Stone E, and Georgiou G. (2018) Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. Nature Biotechnology.36 (8):758-764. PMCID:PMC6078800

Thyagarajan HM, Lancaster JN, Lira SA, Ehrlich LIR. (2018) CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction. PLoS ONE. 13(7):e0200765. PMCID: PMC6053179

2017

LancasterJN, Li Y, Ehrlich LIR. (2017) Chemokine-mediated choreography of thymocyte development and selection.Trends in Immunology. PMCID PMC580097 

Hu Z*, Li Y*, van Nieuwenhuijze A, Selden HJ, Kessler R, Liston A, Ehrlich LIR. (2017) CCR7 modulates the capacity of thymic dendritic cells to induce regulatory T cells. Cell Reports.21(1):168–80. PMCID: PMC5639943

Ki S*, Thyagarajan HM*, Hu Z, Lancaster JN, and Ehrlich LIR. (2017) EBI2 contributes to the induction of thymic central tolerance in mice by promoting rapid motility of medullary thymocytes. EurJ Immunol,14:377.  PMCID: PMC594434 

Lancaster JN and Ehrlich LIR. (2017) Analysis of Thymocyte Migration, Cellular Interactions, and Activation by Multiphoton Fluorescence Microscopy of Live Thymic Slices. Methods Mol Biol: 1591:9–25.(Chapter 2):9–25. PMID: 28349472

2016 

Hu Z, Lancaster JN, Ehrlich LIR*, and Mueller P*. (2016) Detecting T Cell Activation Using a Varying Dimension Bayesian Model. Journal of Applied Statistics.Epub 2017 Feb 16. PMCID: PMC5796679

Nath S, Christian L, Tan SY, Ki S, Ehrlich LIR, Poenie M. (2016) Dynein separately partners with NDE1 and dynactin to orchestrate T cell focused secretion. J Immunol. 197 (6): 2090-2101. PMCID PMC5010990

Ehrlich LIR. (2016) Control of migration during intrathymic T cell development. In Ratcliffe MJH (Editor in Chief), Encyclopedia of Immunobiology. Vol.1, pp. 249-262. Oxford: Academic Press

Triplett TA, Cardenas KT, Lancaster JN, Hu Z, Selden HJ, Jasso G, Balasubramanyam S, Chan K, Li L, Chen X, Marcogliese AM, Dave UP, Love PE, and Ehrlich LIR.(2016) Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation. Proc. Natl. Acad. Sci. USA. 113(8): E1016-25. PMCID PMC4776467

2015

Hu Z, Lancaster JN, Sasiponganan C, Ehrlich LIR.(2015) CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance. Journal of Experimental Medicine.212 (11):1947-1965. PMCID PMC4612092

Hu Z, Lancaster JN, Ehrlich LIR. (2015) The contribution of chemokines and migration to the induction of central tolerance in the thymus. Frontiers in Immunology. 6: 398 DOI:10.3389/fimmu.2015.00398. PMCID PMC4528182

Brown KA, Yang X, Schipper D, Hall JW, DePue LJ, Gnanam AJ, Arambula JF, Jones JN, Swaminathan J, Dieye Y, Vadivelu J, Chandler DJ, Marcotte EM, Sessler JL, Ehrlich LIR, Jones RA. (2015) A self-assembling lanthanide molecular nanoparticle for optical imaging. Dalton Transactions.44(6):2667-2675. PMID 25512085

2014

Ki S*, Park D*, Selden HJ, Seita J, Chung H, Kim J, Iyer VR, Ehrlich LIR. (2014) Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution. Cell Reports. 9:402-415. PMID 25284794

Jones RA, Gnanam AJ, Arambula JF, Jones JN, Swaminathan J, Yang X, Schipper D, Hall JW, DePue LJ, Dieye Y, Vadivelu, J, Chandler DJ, Marcotte EM, Sessler JL, Ehrlich LIR, Brown KA. (2014) Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications. Faraday Discussions. 175:241-255.

Norrie JL, Lewandowski JP, Bouldin CM, Amarnath SR, Li Q, Vokes MS, Ehrlich LIR, Harfe BD, and Vokes SA. (2014) Dynamics of BMP signaling in limb bud mesenchyme and polydactyly. Developmental Biology. 393 (2):270-281.

2013

LiJ, ZhaoZ, Carter C, Ehrlich LIR*, Bedford MT*, Richie ER*. (2013) Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 190(2):597-604.

2012

Seita J, Sahoo D, Rossi DJ, Battacharya D, Serwold T, Inlay MA, Ehrlich LIR, Fathman JW, Dill DL, Weissman IL. (2012) Gene Expression Commons: an open platform for absolute gene expression profiling. PLoS ONE 7(7): e40321.

2011

Ehrlich LIR*, Serwold T*, Weissman IL. (2011) In vitroassays misrepresentin vivolineage potentials of murine lymphoid progenitors. Blood117: 2618-2624.

See Inside Blood: Crooks GM. (2011) Lineage assays: which pathway to take? Blood 117:2560

2010

Ji H*, Ehrlich LIR*, Seita J*, Murakami P, Doi A, Lindau P, Lee H, Aryee M, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, and Feinberg AP. (2010) Comprehensive methylome map of lineage commitment from hematopoietic progenitors. Nature467: 338-42.

Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LIR, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, Mckinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP*, and Daley GQ*. (2010) Epigenetic memory in induced pluripotent stem cells. Nature467: 285-90.

2009

Ehrlich LIR*, Oh DY*, Weissman IL, and Lewis RS. (2009) Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes. Immunity31:986-998.

Faculty of 1000 “must read”: http://f1000biology.com/article/id/1431957/evaluation

See Preview: Swann JB and Boehm T. (2009) Everything in its place. Immunity31: 856-58.

Serwold TS*, Ehrlich LIR*, Weissman IL. (2009) Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Blood 113:807-15.

Faculty of 1000 “recommended”: http://www.f1000biology.com/article/id/1124919/evaluation

 See News and Views: Bunting KD. (2009) CLPs find their inner T-cell potential. Blood113:766-767.

2008

Ebert PJR, Ehrlich LIR, and Davis MM. (2008) Ligand Requirements and Synapse Formation in Thymic Selection. Immunity29:734-45.

Bhatacharrya D, Ehrlich LIR, and Weissman IL. (2008) Space-time considerations for hematopoietic stem cell transplantation. Eur J Immunol.38:2060-7

2005

Ehrlich LIR, Ogasawara K, Hamerman JA, Takaki R, Zingoni A, Allison JP, and Lanier LL. (2005) Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.J Immunol. 174:1922-31. 

2004

Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, and Lanier LL. (2004) NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity20:757-767

2003 

Davis MM, Krogsgaard M, Huppa JB, Sumen C, Prubhoo MA, Irvine DJ, Wu LC, and Ehrlich L.(2003) Dynamics of Cell Surface Molecules During T cell Recognition. Ann Rev Biochem72: 717-742.

Kuhné MR, Lin J, Yablonski D, Mollenauer MN, EhrlichLIR,Huppa J, Davis MM, and Weiss A. (2003) Linker for Activation of T Cells, z-Associated Protein-70, and Src Homology 2 Domain-Containing Leukocyte Protein-76 are Required for TCR-Induced Microtubule-Organizing Center Polarization. J Immunol.171: 860-866.

2002

Ehrlich LIR,Ebert PJR,Krummel MF, Weiss A, Davis MM. (2002) Dynamics of p56lck Translocation to the T Cell Immunological Synapse following Agonist and Antagonist Stimulation. Immunity17: 809-822.

Richie LI, Ebert PJR, Wu LC, Krummel MF, Owen JT, Davis MM. (2002) Imaging synapse formation during thymocyte selection: inability of CD3zto form a stable central accumulation during negative selection. Immunity16: 595-606

2000

Akashi K*, Richie LI*, Miyamoto T, Carr WH, Weissman IL. (2000) B lymphopoiesis in the thymus. J Immunol.164(10): 5221-6.

1998

Mallick-Wood CA, Lewis JM, Richie LI, Owen MJ, Tigelaar RE, Hayday AC. (1998) Conservation of T cell receptor conformation in epidermal gamma delta cells with disrupted primary Vgamma gene usage. Science  279(5357):1729-33.