PUBLICATIONS

*°# Denotes equal contributions

2026

Levine MS, Li J, Ehrlich LIR, DePinho RA, Iverson B, Sessler JL. Viral mimicry may help explain immunogenic cell death. Proc Natl Acad Sci United States Am. 2026;123(11):e2537547123. doi:10.1073/pnas.2537547123

Li T, Ilano A, Arias-Badia M, Luong D, Chang H, Kwek SS, Allaire K, Chumber A, Sakamoto M, Clark M, Lea A, Bridge M, Chen B, Liu E, Porten S, Meng MV, Ehrlich LIR, Oh DY, Fong L. Functionally heterogeneous intratumoral CD4+CD8+ double-positive T cells can give rise to single-positive T cells. Proc Natl Acad Sci United States Am. 2026;123(4):e2506168123. PMCID: PMC12849695

Srinivasan J*, Moore CR*, Calindi A*, Helm BR, Yang Y, Moore JF, Selden HJ, Heiser CN, Liu Q, Lau KS, Ehrlich LIR. The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types. Nat Immunol. 2026;1–16. PMID: 41507389

Jayavelu ND, Samaha H, Wimalasena ST, Hoch A, Gygi JP, Gabernet G, Ozonoff A, Liu S, Milliren CE, Levy O, Baden LR, Melamed E, Ehrlich LIR, McComsey GA, Sekaly RP, Cairns CB, Haddad EK, Schaenman J, Shaw AC, Hafler DA, Montgomery RR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Sesma AF, Simon V, Krammer F, Kraft M, Bime C, Calfee CS, Erle DJ, Langelier CR, Network I, Guan L, Maecker HT, Peters B, Kleinstein SH, Reed EF, Diray-Arce J, Rouphael N, Altman MC. Machine learning models predict long COVID outcomes based on baseline clinical and immunologic factors. Commun Med. 2026;6(1):1. PMCID: PMC12764860

Tipan PG, Ehrlich LIR. Control of migration during intrathymic T cell development. Kaye, Paul, editors. Encyclopedia of Immunobiology (Second Edition). 2026. p. 681–697

2025

Vasudev A*, Moore CR*, Calindi A*, Kang SW*, Helm BR*, Srinivasan J, Shah S, Zong R, Singarapu N, Casey S, Macintyre AN, Lau KS, Hale LP, Liu Q, Manley NR°, Ehrlich LIR°, Richie ER°. Coordinated changes in stromal and hematopoietic cells that define the perinatal to juvenile transition in the mouse thymus. Cell Rep. 2025;44(12):116677. PMID: 41389204

Humphrey RS, Nam S, Wylie DC, Ehrlich LIR. Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling. Blood Neoplasia. 2025;2(3):100095. PMCID: PMC12432516

Jayavelu ND, Qi JJ, Fourati S, Kheradmand F, Langelier CR, Ehrlich LIR, Diray-Arce J, Hoch A, Kraft M, Becker PM, Altman MC, Montgomery RR. Airway Immune Signatures in Severe and Fatal Infection with COVID-19. Am J Respir Cell Mol Biol. 2025;72(6):708–712. PMCID: PMC12143404

Gabernet G*, Maciuch J*, Gygi JP*, Moore JF*, Hoch A, Syphurs C, Chu T, Jayavelu ND, Corry DB, Kheradmand F, Baden LR, Sekaly RP, McComsey GA, Haddad EK, Cairns CB, Rouphael N, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Hough CL, Messer WB, Davis MM, Nadeau KC, Pulendran B, Kraft M, Bime C, Reed EF, Schaenman J, Erle DJ, Calfee CS, Atkinson MA, Brakenridge SC, Melamed E, Shaw AC, Hafler DA, Augustine AD, Becker PM, Ozonoff A, Bosinger SE, Eckalbar W, Maecker HT, Kim-Schulze S, Steen H, Krammer F, Westendorf K, Network I, Peters B, Fourati S, Altman MC, Levy O, Smolen KK, Montgomery RR, Diray-Arce J, Kleinstein SH#, Guan L#, Ehrlich LIR#. A multi-omics recovery factor predicts long COVID in the IMPACC study. J Clin Investig. 2025;2025.02.12.637926. PMCID: PMC11844572

Jayavelu ND, Qi J, Milliren CE, Ozonoff A, Liu S, Levy O, Baden LR, Melamed E, McComsey GA, Cairns CB, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Geng LN, Sesma AF, Simon V, Krammer F, Bime C, Calfee CS, Bosinger SE, Eckalbar W, Steen H, Maecker HT, IMPACC Network, Augustine AD, Diray-Arce J, Haddad EK, Sekaly RP, Kraft M, Woodruff PG, Erle DJ, Ehrlich LIR, Montgomery RR, Becker PM, Altman MC, Fourati S. Type 2 immune responses are associated with less severe COVID-19 in a hospitalized cohort. J Allergy Clin Immunol: Glob. 2025;4(4):100515. PMCID: PMC12284355 

Hou J, Haslund-Gourley B, Diray-Arce J, Hoch A, Rouphael N, Becker PM, Augustine AD, Ozonoff A, Guan L, Kleinstein SH, Peters B, Reed E, Altman M, Langelier CR, Maecker H, Kim S, Montgomery RR, Krammer F, Wilson M, Eckalbar W, Bosinger SE, Levy O, Steen H, Rosen LB, Baden LR, Melamed E, Ehrlich LIR, McComsey GA, Sekaly RP, Schaenman J, Shaw AC, Hafler DA, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Higuita NIA, Metcalf JP, Hough CL, Messer WB, Pulendran B, Nadeau KC, Davis MM, Sesma AF, Simon V, Kraft M, Bime C, Calfee CS, Erle DJ, Network I, Robinson LF, Cairns CB, Haddad EK, Comunale MA. Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study. Front Med. 2025;12:1604388. PMCID: PMC12271175

Langelier C, Glascock A, Maguire C, Phan HV, Lydon E, Calfee C, Network I, Corry D, Kheradmand F, Baden L, Sekaly RP, McComsey G, Haddad E, Cairns C, Pulendran B, Fernandez-Sesma A, Simon V, Metcalf J, Higuita N, Messer W, Davis M, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Atkinson M, Ehrlich LIR, Melamed E, Montgomery R, Shaw A, Hough C, Geng L, Hoch A, Hafler D, Augustine A, Becker P, Peters B, Ozonoff A, Kim-Schulze S, Krammer F, Bosinger S, Eckalbar W, Altman M, Wilson M, Guan L, Maecker H, Steen H, Diray-Arce J, Rouphael N, Kleinstein S, Reed E, Levy O, Chu V. Empiric Azithromycin in COVID-19 Impacts the Respiratory Microbiome and Antimicrobial Resistome without Anti-inflammatory Benefit. Res Sq. 2025;rs.3.rs-6875205. PMCID: PMC12204364

Calindi A, Ehrlich LIR. Intrathymic Regulation of Dendritic Cell Subsets and Their Contributions to Central Tolerance. Immunol Rev. 2025;332(1). PMCID: PMC12117523

Alvarado NS*, Schuler M*, Maguire C, Amengor DA, Nguyen AW, Wilen RE, Rogers J, Bazzi S, Caslin B, DiPasquale C, Abigania M, Olson E, Creaturo J, Hurley K, Triplett TA, Rousseau JF, Strakowski SM, Wylie D, Maynard JA, Ehrlich LIR°, Melamed E°.SARS-CoV-2 humoral immune responses in convalescent individuals over 12 months reveal severity-dependent antibody dynamics. Commun Med. 2025;5(1):149. PMCID: PMC12048490.

Pickering H, Schaenman J, Phan HV, Maguire C, Tsitsiklis A, Rouphael N, Higuita NIA, Atkinson MA, Brakenridge S, Fung M, Messer W, IMPACC Network, Salehi-rad R, Altman MC, Becker PM, Bosinger SE, Eckalbar W, Hoch A, Kim-Schulze S, Kleinstein SH, Krammer F, Diray-Arce J, Levy O, Langelier CR, Salehi-rad R, Altman MC, Becker PM, Bosinger SE, Eckalbar W, Hoch A, Jayavelu ND, Kim-Schulze S, Jenkins M, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Diray-Arce J, Shaw A, Baden L, Levy O, Reed EF, Langelier CR. Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients. Nat Commun. 2025;16(1):586. PMCID: PMC11723965

2024

Wang K, Nie Y, Maguire C, Syphurs C, Sheen H, Karoly M, Lapp L, Gygi JP, Jayavelu ND, Patel RK, Hoch A, Network I, Corry D, Kheradmand F, McComsey GA, Fernandez-Sesma A, Simon V, Metcalf JP, Higuita NIA, Messer WB, Davis MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Hafler DA, Shaw A, Rahman A, Hough CL, Geng LN, Ozonoff A, Haddad EK, Reed EF, Bakel H van, Kim-Schultz S, Krammer F, Wilson M, Eckalbar W, Bosinger S, Langelier CR, Sekaly RP, Montgomery RR, Maecker HT, Krumholz H, Melamed E, Steen H, Pulendran B, Augustine AD, Cairns CB, Rouphael N, Becker PM, Fourati S, Shannon CP, Smolen KK, Peters B, Kleinstein SH, Levy O, Altman MC, Iwasaki A, Diray-Arce J, Ehrlich LIR°, Guan L°. Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping. bioRxiv. 2024;2024.11.22.624784. PMCID: PMC11623532

Maguire C, Chen J, Rouphael N, Pickering H, Phan HV, Glascock A, Chu V, Dandekar R, Corry D, Kheradmand F, Baden LR, Selaky R, McComsey GA, Haddad EK, Cairns CB, Pulendran B, Sesma AF, Simon V, Metcalf JP, Higuita NIA, Messer WB, David MM, Nadeau KC, Kraft M, Bime C, Schaenman J, Erle D, Calfee CS, Atkinson MA, Brackenridge SC, Ehrlich LIR, Montgomery RR, Shaw AC, Hough CL, Geng LN, Hafler DA, Augustine AD, Becker PM, Peters B, Ozonoff A, Kim-Schulze SH, Krammer F, Bosinger S, Eckalbar W, Altman MC, Wilson M, Guan L, Kleinstein SH, Network I, Smolen KK, Reed EF, Levy O, Maecker H, Hunt P, Steen H, Diray-Arce J, Langelier CR, Melamed E. Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19. bioRxiv. 2024;2024.11.14.622799. PMCID: PMC11601417

Kaur H, Heiser CN, McKinley ET, Ventura-Antunes L, Harris CR, Roland JT, Farrow MA, Selden HJ, Pingry EL, Moore JF, Ehrlich LIR, Shrubsole MJ, Spraggins JM, Coffey RJ, Lau KS, Vandekar SN. Consensus tissue domain detection in spatial omics data using multiplex image labeling with regional morphology (MILWRM). Commun Biol.2024;7(1):1295. PMCID: PMC11525554

Lyu A, Nam SH, Humphrey RS, Horton TM, Ehrlich LIR. (2024). Cells and signals of the leukemic microenvironment that support progression of T-cell acute lymphoblastic leukemia (T-ALL). Exp Mol Med;56(11):2337–2347. PMCID: PMC11612169

Araujo AM, Dekker JD, Garrison K, Su Z, Rhee C, Hu Z, Lee BK, Osorio D, Lee J, Iyer VR, Ehrlich LIR, Georgiou G, Ippolito G, Yi S, Tucker HO. Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice. Elife. 2024 Sep 13;13. doi: 10.7554/eLife.96394. PubMed PMID: 39269281; PubMed Central PMCID: PMC11398865.

Phan HV, Tsitsiklis A, Maguire CP, Haddad EK, Becker PM, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, van Zalm P, Altman MC, Augustine AD, Calfee CS, Bosinger S, Cairns CB, Eckalbar W, Guan L, Jayavelu ND, Kleinstein SH, Krammer F, Maecker HT, Ozonoff A, Peters B, Rouphael N, IMPACC Network,  Montgomery RR, Reed E, Schaenman J, Steen H, Levy O, Diray-Arce J, Langelier CR. Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology. Sci Transl Med. 2024 Apr 17;16(743):eadj5154. doi: 10.1126/scitranslmed.adj5154. Epub 2024 Apr 17. PubMed PMID: 38630846.

Haslund-Gourley BS, Woloszczuk K, Hou J, Connors J, Cusimano G, Bell M, Taramangalam B, Fourati S, Mege N, Bernui M, Altman MC, Krammer F, van Bakel H, IMPACC Network, Maecker HT, Rouphael N, Diray-Arce J, Wigdahl B, Kutzler MA, Cairns CB, Haddad EK, Comunale MA. IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition. Nat Commun. 2024 Jan 9;15(1):404. doi: 10.1038/s41467-023-44211-0. PubMed PMID: 38195739; PubMed Central PMCID: PMC10776791.

Gygi JP*, Maguire C*, Patel RK*, Shinde P, Konstorum A, Shannon CP, Xu L, Hoch A, Jayavelu ND,  IMPACC Network, Haddad EK, Reed EF, Kraft M, McComsey GA, Metcalf J, Ozonoff A, Esserman D, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen LB, Bakel Hv, Wilson M, Eckalbar W, Maecker H, Langelier CR, Steen H, Altman MC, Montgomery RR, Levy O, Melamed E, Pulendran B, Diray-Arce J, Smolen KK, Fragiadakis GK, Becker PM, Augustine AD, Sekaly RP, Ehrlich LIR, Fourati S, Peters B, Kleinstein SH, Guan L (2024). Integrated longitudinal multi-omics study identifies immune programs associated with acute COVID-19 severity and mortality. J Clin Investig. 2024;134(9):e176640. PMCID: PMC11060740

Ozonoff A*, Jayavelu ND*, Liu S, Melamed E*, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, MD8, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB , Steen H, Syphurs C, Dandekar R, Shannon CP1, Sekaly RP, Ehrlich LIR, Corry DB, Kheradmand F, Atkinson MA, Brakenridge SC, Agudelo Higuita NI, Metcalf JP, Hough CL, Messer WB,  Pulendran B, , Nadeau, KC, Davis MM, Fernandez Sesma A, Simon V, Bakel Hv, Kim-Schulze S, Hafler DA, Levy O, Kraft M, Bime C, Haddad EK, Calfee CS Erle DJ, Langelier CR, Eckalbar W, Bosinger S, IMPACC Network, Peters B, Kleinstein SH, Reed EF, Augustine AD, Diray-Arce J, Maecker HT, Altman MC °, Montgomery RR°, Becker PM°, Rouphael N°. (2024) Features of acute COVID-19 associated with Post-Acute Sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study. Nature Communications.;15(1):2161.

2023

Srinivasan J, Helm BR, Yang Y, Moore C, Moore JF, Calindi A, Selden HJ, Heiser CN, Liu Q, Lau KS, Ehrlich LIR. (2023) Single-cell transcriptomics reveals heterogenous thymic dendritic cell subsets with distinct functions and requirements for thymocyte-regulated crosstalk. bioRxiv.;2023.12.18.572281

Lyu A*, Humphrey RS*, Nam SH, Durham TA, Hu Z, Arasappan D, Horton TM, and Ehrlich LIR. (2023). Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia. Nat. Commun.14(1):6270. PMCID PMC10560206.

Li Y*, Tipan PG*, Selden HJ, Srinivasan J, Hale LP, Ehrlich LIR. (2023). CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance. eLife 12. doi:10.7554/elife.80443

Diray-Arce J, Fourati S, Jayavelu ND, Patel R, Maguire C, Chang AC, Dandekar R, Qi J, Lee BH, Zalm P van, Schroeder A, Chen E, Konstorum A, Brito A, Gygi JP, Kho A, Chen J, Pawar S, Gonzalez-Reiche AS, Hoch A, Milliren CE, Overton JA, Westendorf K, Network I, Abraham J, Adkisson M, Albert M, Torres LA, Alvarenga B, Anderson ML, Anderson EJ, Arnett A, Asashima H, Atkinson MA, Baden LR, Barton B, Beach K, Beagle E, Becker PM, Bell MR, Bernui M, Bime C, Kumar AB, Booth LJ, Borresen B, Brakenridge SC, Bristow L, Bryant R, Calfee CS, Manuel JC, Carrillo S, Chak S, Chang I, Connors J, Conway M, Corry DB, Cowan D, Croen B, Cruz CSD, Cusimano G, Eaker L, Edwards C, Ehrlich LIR, Elashoff D, Erickson H, Erle DJ, Farhadian S, Farrugia K, Fatou B, Fernandes A, Fernandez-Sesma A, Fragiadakis GK, Furukawa S, Geltman JN, Ghale R, Bermúdez MGC, Goonewardene MI, Sanchez EG, Guirgis FW, Hafler DA, Hamilton S, Harris P, Nemati AH, Hendrickson CM, Agudelo NIH, Hodder T, Holland SM, Hough CL, Huerta C, Hurley KC, Hutton SR, Iwasaki A, Jauregui A, Jha M, Johnson B, Joyner D, Kangelaris KN, Kelly G, Khalil Z, Khan Z, Kheradmand F, Kim JN, Kimura H, Ko AI, Kohr B, Kraft M, Krummel M, Kutzler MF, Lasky-Su J, Lee S, Lee D, Leipold M, Lentucci C, Leroux C, Lin E, Liu S, Love C, Lu Z, Maliskova L, Roth BM, Manohar M, Martens M, McComsey GA, McEnaney K, McLin R, Melamed E, Melnyk N, Mendez K, Messer WB, Metcalf JP, Michelotti G, Mick E, Mohanty S, Mosier J, Mulder LCF, Murphy M, Nadeau KRC, Nelson E, Nelson A, Nguyen V, Oberhaus J, Panganiban B, Pellegrini KL, Pickering HC, Powell DL, Presnell S, Pulendran B, Rahman AH, Sadeed AR, Raskin A, Reed EF, Pereira SR, Rivera AM, Rogers JE, Rogers A, Rogowski B, Rooks R, Rosenberg-Hasson Y, Rothman J, Rousseau JF, Salehi-Rad R, Saluvan M, Samaha H, Schaenman J, Schunk R, Semenza NC, Sen S, Sevransky J, Seyfert-Margolis V, Shaheen T, Shaw AC, Sieg S, Siegel SAR, Sigal N, Siles N, Simmons B, Simon V, Singh G, Sinko L, Smith CM, Smolen KK, Song L-Z, Srivastava K, Sullivan P, Syphurs C, Tcheou J, Tegos GP, Tharp GK, Ally AT, Tsitsiklis A, Ungaro RF, Vaysman T, Viode A, Vita R, Wang X, Ward A, Ward DC, Willmore A, Woloszczuk K, Wong K, Woodruff PG, Xu L, Haren S van, Guchte A van de, Zhao Y, Cairns CB, Rouphael N, Bosinger SE, Kim-Schulze S, Krammer F, Rosen L, Grubaugh ND, Bakel H van, Wilson M, Rajan J, Steen H, Eckalbar W, Cotsapas C, Langelier CR, Levy O, Altman MC, Maecker H, Montgomery RR, Haddad EK, Sekaly RP, Esserman D, Ozonoff A, Becker PM, Augustine AD, Guan L, Peters B, Kleinstein SH. (2023) Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients. Cell Rep Med 4:101079. doi:10.1016/j.xcrm.2023.101079

Srinivasan J*, Vasudev A*, Shasha C, Selden HJ, Perez E, LaFleur B, Sinari SA, Krueger A, Richie ER°, Ehrlich LIR°. The initial age‐associated decline in early T‐cell progenitors reflects fewer pre‐thymic progenitors and altered signals in the bone marrow and thymus microenvironments. Aging Cell [Internet]. 2023;22(8):e13870.

2022

Bazzi SA*, Maguire C *, Holay N, Geltman J, Hurley K, DiPasquale C, Abigania M, Olson E, Ehrlich LIR°, Triplett TA°, Melamed E°. Longitudinal COVID-19 immune trajectories in autoimmune patients on anti-CD20 therapy. Mult Scler Relat Dis. 2022;104195. PMCID: PMC9511881

Al Ozonoff*, Joanna Schaenman*, Naresh Doni Jayavelu*, Carly E. Milliren*, Carolyn S. Calfee, Charles B. Cairns, Monica Kraft, Lindsey R. Baden, Albert C. Shaw, Florian Krammer, Harm van Bakel, Denise A. Esserman, Ana Fernandez Sesma, Viviana Simon, David A. Hafler, Ruth R. Montgomery, Steven H. Kleinstein, Ofer Levy, , Chris Bime, Elias K. Haddad, David J. Erle, Bali Pulendran, R. Kari C. Nadeau, Mark M Davis, Catherine L. Hough, William B. Messer, Nelson I Agudelo Higuita, Jordan P. Metcalf, Mark A. Atkinson, Scott C. Brakenridge, David Corry, Farrah Kheradmand, Laure n I. R. Ehrlich, Esther Melamed, Grace A. McComsey, Rafick Sekaly, Joann Diray-Arce, Bjoern Peters , Alison D. Augustine, Elaine F. Reed, Matthew C. Altman**, Patrice M. Becker**, and Nadine Rouphael**, and the IMPACC study group members. (2022) Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study. eBioMedicine. 83:104208. PMCID: PMC9359694

Lancaster JN*, Keatinge-Clay DE*, Srinivasan J, Li Y, Selden HJ, Nam S, Richie ER, Ehrlich LIR. Central tolerance is impaired in the middle-aged thymic environment. Aging Cell [Internet]. 2022;21(6):e13624. PMCID: PMC9197411

2021

IMPACC Manuscript Writing Team; IMPACC Network Steering Committee. Nadine Rouphael, Holden Maecker, Ruth R Montgomery, Joann Diray-Arce, Steven H Kleinstein, Matthew C Altman, Steven E Bosinger, Walter Eckalbar, Leying Guan, Catherine L Hough, Florian Krammer, Charles Langelier, Ofer Levy, Kerry McEnaney, Bjoern Peters, Adeeb Rahman, Jayant V Rajan, Steven Sigelman, Hanno Steen, Harm van Bakel, Alyssa Ward, Michael R Wilson, Prescott Woodruff, Colin R Zamecnik, Alison D Augustine, Al Ozonoff, Elaine F Reed, Patrice M Becker, Nelson Agudelo Higuita, Matthew C Altman, Mark A Atkinson, Lindsey R Baden, Patrice M Becker, Christian Bime, Scott C Brakenridge, Carolyn S Calfee, Charles B Cairns, David Corry, Mark M Davis, Alison D Augustine, Lauren I R Ehrlich, Elias K Haddad, David J Erle, Ana Fernandez-Sesma, David A Hafler, Catherine L Hough, Farrah Kheradmand, Steven H Kleinstein, Monica Kraft, Ofer Levy, Grace A McComsey, Esther Melamed, William Messer, Jordan Metcalf, Ruth R Montgomery, Kari C Nadeau, Al Ozonoff, Bjoern Peters, Bali Pulendran, Elaine F Reed, Nadine Rouphael, Minnie Sarwal, Joanna Schaenman, Rafick Sekaly, Albert C Shaw, Viviana Simon. (2021)Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study. Sci Immunol. 6(62). doi: 10.1126/sciimmunol.abf3733. PubMed PMID: 34376480

Srinivasan J*, Lancaster JN*, Singarapu N, Hale LP, Ehrlich LIR°, Richie ER°. Age-Related Changes in Thymic Central Tolerance. Front Immunol. 2021 Apr 22; 12:676236. doi:10.3389/fimmu.2021.676236

Wei SC, Meijers WC, Axelrod ML, Anang N-AAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand P-Y,  Mancuso JJ, Himmel LE, Lebrun0Vignes B, Wleklinski MJ, Knollmann BC, Srinivasan J, Li Y, Atolagbe OT, Rao X, Zhao Y, Wang J, Ehrlich LIR, Sharma P, Salem J-E, Balko JM, Moslehi JJ, Allison, JP. A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention. (2021). Cancer Discov. 11(3):614–25. PMCID: PMC8041233

Article Commentary: Young A and Bluestone JA. At the heart of immune checkpoint inhibitor-induced immune toxicity. (2021) Cancer Discov. 11(3):537-9.

2020

Lyu A*, Triplett TA*°, Nam SH, Hu Z, Arasappan D, Godfrey WH, Ames RY, Sarang A, Selden HJ, Lee C-H, Georgiou G, Horton TM, Ehrlich LIR°. (2020) Tumor-associated myeloid cells provide critical support for T-ALL. Blood. 136(16):1837-50.

Article Commentary: Diana Passaro. (2020) Myeloid cells hold the master key for T-ALL spread. Blood. 136 (16): 1799–1800

Warden AS, Triplett TA, Lyu A, Grantham EK, Azzam MM, DaCosta A, Mason S, Blednov YA, Ehrlich LIR, Mayfield DR, and Harris RA. (2020) Microglia depletion and alcohol: Transcriptome and behavioral profiles. Addiction Biology. 29(4):e12889

2019

Lancaster JN, Thyagarajan HM, Srinivasan J, Li Y, Hu Z, Ehrlich LIR. (2019) Live-cell imaging reveals the relative contributions of antigen presenting cell subsets to thymic central tolerance. Nature Communications.10(1):2220. link: https://rdcu.be/bCTkA

see: https://cns.utexas.edu/news/scientists-capture-first-ever-video-of-body-s-safety-test-for-t-cells

Jarrett AM, Bloom M, Godfrey W, Syed A, Ekrut DA, EhrlichLIR, Yankeelov TE, Sorace AG (2019) Mathematical modeling of trastuzumab-induced immune response in an in vivo murine model of HER2+ breast cancer.  Mathematical Medicine and Biology. 15: 730. PMID 30239754

2018

Singarapu N, Ma K, Reeh KAG, Shen J, Lancaster JN, Xie H, Orkin S, Manley NR, Ehrlich LIR, Jiang N, Richie ER.(2018) Polycomb Repressive Complex 2 is essential for development and maintenance of a functional TEC compartment. Scientific Reports. 8(1):14335. PMCID: PMC6156232

Triplett TA, Garrison KC, Marshall N, Donkor M, Blazeck J, Lamb C, Qerqez A, Dekker JD, Tanno Y, Lu WC, Karamitros CS, Ford K, Tan B, Zhang M, McGovern K, Coma S, Kumada Y, Yamany MS, Sentandreu E, Fromm G, Tiziani S, Schreiber TH, Manfredi M, Ehrlich LIR, Stone E, and Georgiou G. (2018) Reversal of IDO-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. Nature Biotechnology.36 (8):758-764. PMCID:PMC6078800

Thyagarajan HM, Lancaster JN, Lira SA, Ehrlich LIR. (2018) CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction. PLoS ONE. 13(7):e0200765. PMCID: PMC6053179

2017

LancasterJN, Li Y, Ehrlich LIR. (2017) Chemokine-mediated choreography of thymocyte development and selection.Trends in Immunology. PMCID PMC580097 

Hu Z*, Li Y*, van Nieuwenhuijze A, Selden HJ, Kessler R, Liston A, Ehrlich LIR. (2017) CCR7 modulates the capacity of thymic dendritic cells to induce regulatory T cells. Cell Reports.21(1):168–80. PMCID: PMC5639943

Ki S*, Thyagarajan HM*, Hu Z, Lancaster JN, and Ehrlich LIR. (2017) EBI2 contributes to the induction of thymic central tolerance in mice by promoting rapid motility of medullary thymocytes. EurJ Immunol,14:377.  PMCID: PMC594434 

Lancaster JN and Ehrlich LIR. (2017) Analysis of Thymocyte Migration, Cellular Interactions, and Activation by Multiphoton Fluorescence Microscopy of Live Thymic Slices. Methods Mol Biol: 1591:9–25.(Chapter 2):9–25. PMID: 28349472

2016 

Hu Z, Lancaster JN, Ehrlich LIR*, and Mueller P*. (2016) Detecting T Cell Activation Using a Varying Dimension Bayesian Model. Journal of Applied Statistics.Epub 2017 Feb 16. PMCID: PMC5796679

Nath S, Christian L, Tan SY, Ki S, Ehrlich LIR, Poenie M. (2016) Dynein separately partners with NDE1 and dynactin to orchestrate T cell focused secretion. J Immunol. 197 (6): 2090-2101. PMCID PMC5010990

Ehrlich LIR. (2016) Control of migration during intrathymic T cell development. In Ratcliffe MJH (Editor in Chief), Encyclopedia of Immunobiology. Vol.1, pp. 249-262. Oxford: Academic Press

Triplett TA, Cardenas KT, Lancaster JN, Hu Z, Selden HJ, Jasso G, Balasubramanyam S, Chan K, Li L, Chen X, Marcogliese AM, Dave UP, Love PE, and Ehrlich LIR.(2016) Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation. Proc. Natl. Acad. Sci. USA. 113(8): E1016-25. PMCID PMC4776467

2015

Hu Z, Lancaster JN, Sasiponganan C, Ehrlich LIR.(2015) CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance. Journal of Experimental Medicine.212 (11):1947-1965. PMCID PMC4612092

Hu Z, Lancaster JN, Ehrlich LIR. (2015) The contribution of chemokines and migration to the induction of central tolerance in the thymus. Frontiers in Immunology. 6: 398 DOI:10.3389/fimmu.2015.00398. PMCID PMC4528182

Brown KA, Yang X, Schipper D, Hall JW, DePue LJ, Gnanam AJ, Arambula JF, Jones JN, Swaminathan J, Dieye Y, Vadivelu J, Chandler DJ, Marcotte EM, Sessler JL, Ehrlich LIR, Jones RA. (2015) A self-assembling lanthanide molecular nanoparticle for optical imaging. Dalton Transactions.44(6):2667-2675. PMID 25512085

2014

Ki S*, Park D*, Selden HJ, Seita J, Chung H, Kim J, Iyer VR, Ehrlich LIR. (2014) Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution. Cell Reports. 9:402-415. PMID 25284794

Jones RA, Gnanam AJ, Arambula JF, Jones JN, Swaminathan J, Yang X, Schipper D, Hall JW, DePue LJ, Dieye Y, Vadivelu, J, Chandler DJ, Marcotte EM, Sessler JL, Ehrlich LIR, Brown KA. (2014) Lanthanide nano-drums: A new class of molecular nanoparticles for potential biomedical applications. Faraday Discussions. 175:241-255.

Norrie JL, Lewandowski JP, Bouldin CM, Amarnath SR, Li Q, Vokes MS, Ehrlich LIR, Harfe BD, and Vokes SA. (2014) Dynamics of BMP signaling in limb bud mesenchyme and polydactyly. Developmental Biology. 393 (2):270-281.

2013

LiJ, ZhaoZ, Carter C, Ehrlich LIR*, Bedford MT*, Richie ER*. (2013) Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 190(2):597-604.

2012

Seita J, Sahoo D, Rossi DJ, Battacharya D, Serwold T, Inlay MA, Ehrlich LIR, Fathman JW, Dill DL, Weissman IL. (2012) Gene Expression Commons: an open platform for absolute gene expression profiling. PLoS ONE 7(7): e40321.

2011

Ehrlich LIR*, Serwold T*, Weissman IL. (2011) In vitroassays misrepresentin vivolineage potentials of murine lymphoid progenitors. Blood117: 2618-2624.

See Inside Blood: Crooks GM. (2011) Lineage assays: which pathway to take? Blood 117:2560

2010

Ji H*, Ehrlich LIR*, Seita J*, Murakami P, Doi A, Lindau P, Lee H, Aryee M, Irizarry RA, Kim K, Rossi DJ, Inlay MA, Serwold T, Karsunky H, Ho L, Daley GQ, Weissman IL, and Feinberg AP. (2010) Comprehensive methylome map of lineage commitment from hematopoietic progenitors. Nature467: 338-42.

Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LIR, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, Mckinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP*, and Daley GQ*. (2010) Epigenetic memory in induced pluripotent stem cells. Nature467: 285-90.

2009

Ehrlich LIR*, Oh DY*, Weissman IL, and Lewis RS. (2009) Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes. Immunity31:986-998.

Faculty of 1000 “must read”: http://f1000biology.com/article/id/1431957/evaluation

See Preview: Swann JB and Boehm T. (2009) Everything in its place. Immunity31: 856-58.

Serwold TS*, Ehrlich LIR*, Weissman IL. (2009) Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis. Blood 113:807-15.

Faculty of 1000 “recommended”: http://www.f1000biology.com/article/id/1124919/evaluation

 See News and Views: Bunting KD. (2009) CLPs find their inner T-cell potential. Blood113:766-767.

2008

Ebert PJR, Ehrlich LIR, and Davis MM. (2008) Ligand Requirements and Synapse Formation in Thymic Selection. Immunity29:734-45.

Bhatacharrya D, Ehrlich LIR, and Weissman IL. (2008) Space-time considerations for hematopoietic stem cell transplantation. Eur J Immunol.38:2060-7

2005

Ehrlich LIR, Ogasawara K, Hamerman JA, Takaki R, Zingoni A, Allison JP, and Lanier LL. (2005) Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.J Immunol. 174:1922-31. 

2004

Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, and Lanier LL. (2004) NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity20:757-767

2003 

Davis MM, Krogsgaard M, Huppa JB, Sumen C, Prubhoo MA, Irvine DJ, Wu LC, and Ehrlich L.(2003) Dynamics of Cell Surface Molecules During T cell Recognition. Ann Rev Biochem72: 717-742.

Kuhné MR, Lin J, Yablonski D, Mollenauer MN, EhrlichLIR,Huppa J, Davis MM, and Weiss A. (2003) Linker for Activation of T Cells, z-Associated Protein-70, and Src Homology 2 Domain-Containing Leukocyte Protein-76 are Required for TCR-Induced Microtubule-Organizing Center Polarization. J Immunol.171: 860-866.

2002

Ehrlich LIR,Ebert PJR,Krummel MF, Weiss A, Davis MM. (2002) Dynamics of p56lck Translocation to the T Cell Immunological Synapse following Agonist and Antagonist Stimulation. Immunity17: 809-822.

Richie LI, Ebert PJR, Wu LC, Krummel MF, Owen JT, Davis MM. (2002) Imaging synapse formation during thymocyte selection: inability of CD3zto form a stable central accumulation during negative selection. Immunity16: 595-606

2000

Akashi K*, Richie LI*, Miyamoto T, Carr WH, Weissman IL. (2000) B lymphopoiesis in the thymus. J Immunol.164(10): 5221-6.

1998

Mallick-Wood CA, Lewis JM, Richie LI, Owen MJ, Tigelaar RE, Hayday AC. (1998) Conservation of T cell receptor conformation in epidermal gamma delta cells with disrupted primary Vgamma gene usage. Science  279(5357):1729-33.